Particularly Hazardous Chemical Definitions
A particular chemical substance and associated laboratory operation, procedure, or activity considered sufficiently hazardous to require prior approval.
The following classes of chemical are considered particularly hazardous:
- The LC50 (inhalation) = <200ppm
- The LD50 (dermal route) = < 200 mg/kg body weight
- The LD50 (ingestion) = < 50 mg/kg body weight.
- It is regulated by OSHA as a carcinogen
- It is classified as a “Known” or “Anticipated” carcinogen by the National Toxicology Program (NTP)
- It is classified as a “1, Human”, “2A, Probable”, or “2B, Possible” carcinogen by the International Agency for Research on Cancer (IARC)
If the project is funded, the following requirements must be met:
- An updated Chemical Hygiene Plan.
- The development of a Standard Operating Procedure (SOP) specific to that task.
- SOPs should address: instruction for the safe use of the chemical, consideration or assignment of “designated areas” for material use, use of containment devices, personal protective equipment, and instructions regarding handling of contaminated waste, spill response procedures, and decontamination procedures.