Eye Irritant
Changes in the eye following the application of a test substance to the front surface of the eye, which are fully reversible within 21 days of application. Serious eye damage means production of tissue damage in the eye, or serious physical decay of vision, following application of a test substance to the front surface of the eye, which is not fully reversible within 21 days of application.
Draize score:
Corneal Opacity ≥ 3
Iritis > 1.5
Irritant Subcategory 2A
- Reversible in 21 days
- Reversible in 7 days
Corneal Opacity ≥ 1
Iritis ≥ 1
Redness ≥ 2
Chemosis ≥ 2
Skin Irritant
The production of reversible damage to the skin following the application of a test substance for up to four hours. Substances and mixtures in this hazard class are assigned to a single irritant category.
- Destruction of dermal tissue: visible necrosis in at least one animal (3 col)
- Exposure < 3 min
- Observation <1 hr
- Exposure < 1 hr
- Observation < 14 days
- Exposure < 4hr
- Observation < 14 days
- Reversible adverse effects in dermal tissue
or Persistent Inflammation
- Reversible adverse effects in dermal tissue
Skin Sensitizer
A substance that will induce an allergic response following skin contact. The definition for “skin sensitizer” is equivalent to “contact sensitizer.” Substances and mixtures in this hazard class are assigned to one hazard category. Consideration should be given to classifying substances which cause immunological contact urticaria (an allergic disorder) as contact sensitizers.
Narcotic Effects
Narcotic effects and respiratory tract irritation are considered to be target organ systemic effects following a single exposure to any class of substances that blunt the senses.