Five GHS categories have been included in the GHS Acute Toxicity scheme from which the appropriate elements relevant to transport, consumer, worker, and environment protection can be selected. Substances are assigned to one of the five toxicity categories on the basis of LD50 (oral, dermal) or LC50 (inhalation).
| Category 1 | Category 2 | Category 3 | Category 4 | |
|---|---|---|---|---|
| Oral (mg/kg) | ≤ 5 | < 5 and ≤ 50 | < 50 and ≤ 300 | < 300 and≤ 2000 |
| Dermal (mg/kg) | ≤ 50 | < 50 and ≤ 200 | < 200 and ≤ 1000 | < 1000 and ≤ 2000 |
| Gases (ppm) | ≤ 100 | < 100 and ≤ 500 | < 500 and ≤ 2500 | < 2500 and ≤ 5000 |
| Vapors (mg/l) | ≤ 0.5 | < 0.5 and ≤ 2.0 | < 2.0 and ≤ 10 | < 10 and ≤ 20 |
| Dusts & Mists (mg/l) | ≤ 0.05 | < 0.05 and ≤ 0.5 | < 0.5 and ≤ 1.0 | < 1.0 and ≤ 5 |
- Anticipated oral LD between 2000 and 5000 mg/kg;
- Indication of significant effect in humans;*
- Any mortality at class 4;*
- Significant clinical signs at class 4;*
- Indications from other studies;*